By Sydney M. Finegold, W. Lance George
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Human coronaviruses prompted the SARS epidemic that contaminated greater than 8000 humans, killing approximately ten percentage of them in 32 international locations. This publication presents crucial details on those viruses and the improvement of vaccines to regulate coronavirus infections.
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T h e r e m a y b e strain variation in the a m o u n t of e n z y m e p r o d u c e d (Smith, 1975). H e w i t t and Morris found m o d e r a t e activity in a strain of Clostridium perfringens (Hewitt and Morris, 1975), but Tally and co-workers found only low levels in other strains of this species (Tally et ai, 1975a,c). T h e latter w o r k e r s noted that there w a s general, but not universal, correlation b e t w e e n the degree of aerotolerance and the a m o u n t of superoxide d i s m u t a s e p r o d u c e d .
Ueber bakteriologische Untersuchungen und ihre Methoden bei Febris puerperalis. Munch. Med. Wochenscht. 1, 787-789. Seddon, H. R. (1922). The specific identity of Bacillus parabotulinus. J. Comp. Pathol. 35, 275-280. Smith, J. W. , Evans, D. , and Batten, R. C. (1965). Experimental studies of tetanus prophylaxis. Proc. R. Soc. Med. 58, 226-227. Stone, M. L. (1940). Studies on the anaerobic streptococci. I. Certain biochemical and immunological properties of anaerobic streptococci. J. Bacteriol.
Although the clinical value of gas gangrene antitoxin was largely o v e r s h a d o w e d by the introduction of penicillin, the impact of the antibiotic on both prophylaxis and t h e r a p y w a s uniformly disappointing. Surgery remained the essential mainstay of m a n a g e m e n t : " T h e surgical m e a s u r e s d e m a n d e d in true gas gangrene consist of an uncompromising excision of gangrenous and infected muscular tissue. W h e r e one muscle, or one group of m u s c l e s , is involved, that muscle, or muscle-group, must be extirpated from origin to insertion.
Anaerobic infections in humans by Sydney M. Finegold, W. Lance George